In the past, there were many studies on the overall concept of health preservation in Shen Nong's Materia Medica, and most of them were limited to the attention of "high-grade medicines". In order to explore the understanding and application characteristics of life-extending medicines in Shen Nong's Materia Medica, the author made a preliminary analysis of the records of medicines with "life-extending" efficacy in the book, and consulted 100 medicines in total, Among them, there are 93 kinds of high-grade medicines (cinnabar, mica, Yuquan, stalactite, ettringite, talc, bile alum, Kongqing, Zengqing, Yuyuliang, white quartz, amethyst quartz, red stone fat, white stone fat, yellowstone fat, black stone fat, blue stone fat, white green, flat green, calamus, chrysanthemum, ginseng, asparagus, licorice, dried rehmannia glutinosa, atractylodes macrocephala, dodder seed, achyranthes bidentata, polygonatum odoratum, ophiopogon japonicus, duhuo, plantain, yam, alisma, polygala, gentian, asarum, dendrobium, white herb, white artemisia, gastrodia elata, palm seed, thorn seed, root seed, red lucidum, green lucidum, yellow lucidum, white lucidum, black lucidum, purple lucidum, luoshi vine, puhuang, cattle ruminant, leak, Tianmingjing, orchid grass, cochlea fruit, Yin Chen, Shilongqi, Wang Buliuxing, Cimicifuga, Qingkonjac, Guhuo, Qucao, Osmanthus guinea, rosin, Lycium barbarum, Cypress kernel, Poria cocos, Ziziphus jujube kernel, dry lacquer, Vitex, Xinyi, Eucommia ulmoides, Ligustrum lucidum, dragon tooth, staghorn glue, goose fat, honey, bee, beeswax, oyster, lotus seed, jujube, grape, Peng, Gorgon fruit, flax, hemp seeds, winter sunflower seeds, winter melon seeds, bitter vegetables); 6 kinds of traditional Chinese medicines (estradix, mercury, shilongrui, root, salvia, stachyx); One kind of low-grade medicine (Shu Pepper).