1993年 · 第09卷第05期

Lymphocyte subsets in peripheral blood were observed before and after the treatment of intravenous cyclosphosphamide, cyclosporine A, pulse methylprednisolone in 27 patients with refractory lupus nephritis. The effective groups in each parement have a high numbers of CD₈⁺ cell phenotype in Ⅳ-CTX, CD₄⁺ cell phenotype in CsA and both CD₄⁺ and CD₈⁺ cells in Ⅳ-MP as compared with ineffective groups. This result indicated that lymphocyte subsets in peripheral blood may help to choose the parement in refractory lupus nephritis.

Renal biopsies from rabbits with nephrotoxic nephritis were made in order to investigate the product of lipid hydroperoxidation-malondialdehyde (MDA) and the inhabitor superoxide dismutase (SOD) At the early and middle stages of the nephrotoxic nephritis, the levels of the rabbits renal tissue MDA is higher than that at the normal state; the activity of SOD become low from early stage to the end in the nephrotoxic nephritis kidney. The results suggest that the increased lipid hydroperoxide by oxygen radicals and the depressed ability of the antioxidation in the kidney play an important role in the development of the nephrotoxic nephritis.

Urinary histamine levels were detected in 34 children with INS in different stages. The results showed the level of urinary histamine in active stage was lower than that of normal controls (P<0.01), in s remission it was markedly increased (P<0.01), In nephrotic phase the patients' response to steroids was closely related to the level of urinary histamine, and the variation of a series of urinary histamine levels within 8 weeks may play a role in predicting the patients' relapse and response to steroids.