1992年 · 第08卷第03期

Thirty-two children with primary nephrotic syndrome and forty healthy adults were studied for neutrophil chemotaxis, plasma che motactic activity and chemotactic inhibitors. The patients had depressed neutrophil chemotactic index and plasma chemotactic activity in active phase but normalized ones in remission. No inhibitors were found. Impaired neutrophil chemotaxis was associated with activity of nephrotic syndrome. In streoid-sensitive cases neutrophil chemotactic index was significantly lowered in non-steroid ones. These results suggested that neutrophil chemotaxis might play a role in pathogenesis of nephrotic syndrome.

The changes of negative charge on RBC and glomeruli were studied by alcian blue staining and electron computerized picture analysis respectively.

The results showed that the negative charge on RBC and glomeruli decreased significantly in nephrotic children and this change was related to the active stage of nephrotic syndrome. There was a positive relation between the changes of negative charge on glomeruli and those on RBC. There was no difference between the different pathologic group or clinic group about the change of negative charge on RBC and glomeruli in nephrotic syndrome.