1992年 · 第08卷第02期

our results showed that the level of plasma LPO was found higher in CGN patients than in normal controls. We found a significant positive correlation of LPO to creatinine and BUN. The activity of SODin RBC was found lower in CGN patients than in normal controls The results indicated tha one of reasons of glomerulus in jury was the alteration of the level of plasma LPO and the activity of SOD in RBC in CGN patients.

SOD, G-Px, and CAT activities in RBC and MDA, Scr, BUN contents in serum of 238 healthy individuals in four groups were measured. The results showed that (1) SOD, G-Px, and CAT activities decreased; and MDA, corrected Scr, and BUN contents elevated with increase of age gradually. The group in age 15~ and 30~ was significantly different from the group in age 50~ and 65~ (P<0.01); (2) There were negative correlation separately between SOD, G-Px, and CAT activites and corrected Scr, BUN contents. There were positive correlation between MDA and corrected SCr, BUN. We concluded that the decline of antioxidation enzyme activities and the increase of lipoperoxidation level was one of important factors for aging and degeneration of renal function in aged.

In order to explore the asscciation of Fc receptor (FcR) expression in patients with chronic renal failure (CRF) with their defects of imnunity, FcR (for IgG) in peripheral blood lymphocytes(PBL), labeled with biotihlated aggregated IgG and avidin Conjugated FITC were analysed. It was found that FcR (for IgG) was abnormally expressed in the lymphocytes of the patients. The percentage of FcR positive PBL in CRF patients (18.33±4.12) was significantly reduced as compared with health controls (32.89±8.71) (P<0.001). These results imply that the abnormal FcR expression may play a key role in the developments of CRF.

Japan rabbits were injected intramuscularly with mercuric chloride (MC) over prolonged of time to test the hypothesis that MC can modify autologous antigens (or release autologous antigens) generating an autoimmune response and antibody-mediated nephritis. The results of studies by immunofluorescence showed that prolonged administration of small doses MC frequently induces biphasic autoimmune glomerulonephritis characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition.

We measured erythrocytemembrane cholesterol malonyldialdehyde (MDA), an end product of lipid peroxidation and erythrocyte glutathione peroxidase (GSH-PP) activity in the same time to measure plasma lipid compositions The results obtained in our study showed that the erythrocyte membrane cholesterol and MDA in CRF group were significantly increased (p<0.01), and in positive correlation to nitride in blood. Erythrocyte GSH-PX activity was lower than that in controls (<0.01), and in negative correlation to plasma lipid Our study would suggest that the lipocatabolic disturbance in CRF may be one of factors linking to the erythrocyte membrane composition abnormalities