1992年 · 第08卷第04期

The therapeutic effects of Dexamethasomun, Isoptin, Radix Salviac Miltiorrhizae, Pollen Typhae, Radix et Rhizoma Rhei on early kidney damage of rats caused by fish bile were observed. These drugs were effective to reduce blood creatinine, urinary NAG, number of necrosed epithelial cells of proximal tubule and of glomerulus filled with RBC in Bowman's space, and effective to increase creatinine clearance. The results provide treatment methods for fish bile poisoning.

The nephrotic rats made by injection of puromycine were divided into four groups, with or without A&A, high-prot-ein-diet (27.3%) or low-protein-diet (18.1%). The observation period lasted 15 days. The dynamic study used 15N-glycine as a tracer was performed at the 14th day of the experiment. We found that the hypoalbuminemia in nephrotic rats could be improved little by either feeding A&A or increasing the protein intake. The rate of the protein synthesis of the rats, who were both fed on high-protein-diet and given A&A, increased markedly, while the rate of protein breakdown did not change. Their serum albumin remained in normal range, though the heavy proteinuria still existed.