Oral and maxillofacial diseases include infection, inflammation, trauma, tumor, etc., which extensively involve soft and hard tissues such as teeth, bones, mucosa, glands, etc. These diseases can cause defects, dysfunction or loss of maxillofacial tissues and organs, and affect the progress of systemic diseases and general health, seriously threatening people's physical and mental health. At present, treatment is limited by the self-repair ability of body tissues. When oral and maxillofacial tissues and organs face defects or absences, traditional treatment methods can't completely restore the shape and function of tissues and organs. Most of the popularization and application of new technologies are based on the original treatment methods. Based on the improvement and perfection, the curative effect is limited. With the vigorous development of regenerative medicine represented by stem cells and biomaterials, a new door has been opened for the treatment of oral diseases, and new treatment strategies have been introduced.