In this issue of the Chinese Journal of Thoracic and Cardiovascular Surgery, Beijing Chaoyang Hospital affiliated to Capital Medical University published a retrospective study on the use of anticoagulants to prevent venous thromboembolism (VTE) in patients undergoing lung surgery in the center during the perioperative period[1]。 Studies have shown that despite the use of preventive measures such as anticoagulants during the perioperative period, the incidence of VTE after pulmonary surgery is not significantly reduced, and some are even higher than those in the non-anticoagulant prevention group. The results were disappointing, so the reviewers considered the results to be negative and not clinically significant. After receiving the review comments, our research group conducted a careful discussion and analysis, trying to explore what factors caused the results of this study to be inconsistent with the opinions recommended by relevant guidelines at home and abroad. Is anticoagulation prevention really ineffective? Or is the stratification of high-risk patients inaccurate? Or are there other reasons for this result? This article will explain our views one by one around these issues.