2016年 · 第36卷第10期

With the application of nuclear energy and radiation technology in many fields such as industry, agriculture, medicine and national defense, it is a very important research topic to find effective radiation protection drugs to deal with radiation damage in nuclear and radiation emergencies and medical accidents^[1,2]。 probucol is a synthetic antioxidant with the strongest antioxidant effect in clinical application. It has antioxidant, anti-inflammatory and anti-atherosclerotic effects^[3]。 However, serious adverse reactions (such as gastrointestinal reactions, headache, dizziness, insomnia, tinnitus, etc.) limit its clinical application. This study aims to construct a biocompatible polymer micelle with cell membrane structure to effectively encapsulate hydrophobic probucol, and explore whether it can reduce adverse drug reactions and enhance its radiation protection effect.

The radioactivity level of water is an important index for monitoring radioactive pollution of water quality. Drinking water is closely related to people's life, so whether drinking water is polluted by radioactivity is a general concern^[1]。 Usually inhabitants' internal exposure is caused by drinking water and feeding, and water is one of the main ways for humans to ingest natural and artificial radionuclides. Estimating the average annual effective dose of inhabitants' internal exposure caused by drinking water can understand the impact of drinking water on public health^[2]。 The level of total alpha and total beta radioactivity in water can be an important indicator for water quality radioactivity monitoring. The WHO publication "Guidelines for Drinking Water Quality" recommends that when total alpha and total beta activity in water exceeds either of the screening levels (0.5 and 1 Bq/L, respectively), certain specific radionuclides that produce this activity value should be identified and the activity concentration of each of them should be measured^[3]。 At present, regarding the total radioactivity monitoring of factory water in Hohhot, Shen Na et al^[4]It has been reported, but the detailed monitoring and analysis of radionuclides in water has not been reported. In this study, the total radioactivity and radioactivity of specific nuclides were measured and analyzed by collecting the factory water from all nine water plants in Hohhot City, and the average annual effective dose of inner exposure caused by drinking water was estimated.

In recent years, with the gradual improvement of radiation protection conditions in medical institutions at all levels, the average annual effective dose of radiation workers has been decreasing year by year. However, the annual effective dose of individuals in different radiation diagnosis and treatment subjects is still quite different, and individual radiation workers even exceed the survey level and annual dose limit^[1,2]。 According to the survey results from 2003 to 2007 in Henan Province, the average annual effective dose of radiation workers in all radiation diagnosis and treatment subjects is ranked according to high and low, and interventional radiology ranks first^[1]。 In order to dynamically observe the change trend of personal dose monitoring results of interventional radiology workers (hereinafter referred to as interventional workers), find the problems existing in the monitoring process and the main factors affecting the personal dose monitoring results, 19 medical institutions carrying out interventional radiology monitored by Henan Institute of Occupational Disease Prevention and Control in the province were selected for personal dose monitoring, and the questionnaire of personal dose monitoring results and suspicious results from 2010 to 2014 was consulted and statistically analyzed, so as to put forward suggestions for improving the radiation protection conditions of interventional workers, reducing the exposure dose and improving the quality of personal dose monitoring.

CT is an X-ray examination device that has emerged in recent years, and it has incomparable advantages than other X-ray devices in clinic. However, it is an indisputable fact that the radiation dose caused by CT scan is large. In its 2008 report, the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) noted that although CT examination accounts for only 7.9 percent of all medical diagnostic X-ray examinations worldwide, it causes about 43 percent of the public collective dose^[1]。 The International Commission for Radiological Protection (ICRP), in its Publication No. 102, cites that absorbed dose of organs and tissues caused by CT can often approach or exceed levels known to increase the probability of cancer^[2]。