2017年 · 第26卷第03期

Survivin single gene encodes human 17q25 chromosome (3% distal to telomere), with a relative molecular mass of 16500, which is the smallest member of the apoptosis inhibitor protein family^[1]。 Survivin has dual functions of inhibiting apoptosis and regulating cell cycle. Compared with other regulatory genes, the advantage is that they are selectively expressed in tumor tissues, almost all of which are expressed in many human malignancies and low or no expression in adult terminally differentiated tissues^[2,3,4]Its unique structure and properties have become the focus of attention. Marioni et al.^[5]Scholars have found that the high expression of survivin in laryngeal cancer with high recurrence rate and short recurrence interval is closely related to radiation resistance, suggesting that inhibiting survivin in laryngeal cancer may be effective to improve radiosensitivity. To confirm this hypothesis, this study evaluated the effect of survivin shRNA on radioresistance of laryngeal carcinoma cells.

The expression of miR-145 is low in various tumor tissues, and it also plays a role in radiosensitivity^[1,2]。 HLTF is a helicase-like transcription factor. As a cancer-related transcription factor, it has been studied in digestive tract tumors such as cardia cancer. HLTF can enhance the ability of cellular DNA damage repair, and its upregulated expression is related to radiation tolerance of cervical cancer. Based on previous studies, the author studied the effect of miR-145 on cervical cancer Me180 cells, so as to explore its mechanism of action in the treatment of cervical cancer.

Therapeutic position and body fixation are an extremely important part in the execution of radiotherapy planning and positioning. Studies have shown that the therapeutic gain ratio in radiotherapy is negatively correlated with the error caused by multiple positioning during radiotherapy^[1,2,3,4]。 Spinal deformity refers to the abnormal deformation of the anatomical structure of the spine. From the appearance, spinal deformity is mainly divided into scoliosis and kyphosis. In clinical radiotherapy, some tumor patients are accompanied by different degrees of spinal deformity. Due to the deformity of back bulge, poor flatness, asymmetry and balance of joints and bones, it is more difficult and more demanding to fix the position of treatment. The determination of the treatment position should not only take into account the requirements of the field, but also take into account the general health condition of the patient, and the repeatability of the position during each positioning^{[3,4,5,6,7,8]}。 In this paper, we will compare the positioning error between vacuum bag and conventional thermoplastic membrane positioning technique in radiotherapy of thoracic and abdominal tumors with spinal deformity, and select the appropriate positioning technique for radiotherapy to be popularized and applied.