Volume 96  ·   Issue 08  ·  1983

The authors find that early post trauma depression of thyroxin, insulin and cortisol secretion yields poor prognosis, as do lower insulin/glucose (I/G) ratios. Cortisol administration is given those with low levels during shock for only a limited period in order to prevent side effects. In order to improve insulin and blood glucose intake in the early stage, GIK therapy should be considered. Further study of thyroxin and its metabolic effects is needed.

Theoretically, 15 types of Robertsonian translocation in man are to be expected. However, only 14 of them seem to be found up to the present. It has been almost a common conviction that 14q14q translocation is nonexistent. In view of the incomplete data in Casperssoin et al's paper a 14q14q case reported in 1971 might not be very convincing. This study using modern cytogenetic technics (including general G-banding, C-banding, high resolution and silver-staining method) on a man whose wife experienced habitual abortions 7 times proved that he was a true carrier of homologous 14q14q Robertsonian translocation. The potential genetic risk caused by the translocation carrier is discussed and a hypothesis is advanced to explicate the origin of this type of homologous 14q14q translocation.

LACA, CFW and Shanghai strain albino mice, 10 weeks old are whole-body irradiated at a lethal gamma-ray dose and treated with bone marrow transplantation (BMT). A high rate of cataract formation is observed in these mice. The cataracts develop within a short period and progress rapidly, they are not ca.used by natural senility, nutritional condition or BMT but by irradiation. Clinical use of BMT may in time save acute radiation sickness patients receiving lethal irradiation when the technic is perfected. In this condition there is high probability of radiation cataracts, therefore effective prophylactic drugs should be developed. Owing to absence of blood vessels in the lens, radioprotective drugs of short duration do not reach effective concentrations in lens cells, so it is important to develop effective drugs.

This is a retrospective study of 430 patients with bone lesions with fine-needle cytologic examination during the past 10 years (1970-1979) in our hospital. The cytologically examined lesions can be classified into 3 groups, inflammatory, tumor-like and tumorous. 54 of the 430 patients were operated upon and most of the bone lesions were proven to be tumorous and tumor-like by postoperative histologic study. In correlating the histologic study and preoperative fine needle cytologic examination, it is found that fine needle biopsy is completely compatible with the histology results in 76% of the cases, partially compatible in 13% and incompatible in 11%, showing that fine-needle biopsy is an appropriate means for identifying bone tumors and tumor-like lesions if sufficient tumor cells are observed in aspiration specimens. The morphology of several common bone tumors is described in detail and their differential diagnosis discussed. Although cytodiagnosis of considerable value in recognizing bone tumors, it cannot replace histologic biopsy. Frozen biopsies as well as regular sections should still be taken during surgery.

Our results show that both A1-fetoprotein (AFP) and A1-antitrypsin (AAT) tend to increase simultaneously in all but a few cases of primary hepatocellular carcinoma (PHC), but it is better to use both assays for accurate PHC diagnosis.

This paper introduces the new method of intraluminal thread and silver clips to occlude the oviducts to produce female sterilization. On the basis of experimental studies, we designed some tools and improved the technic. Since December 1979, we have used this method clinically in 124 cases, the clinical observations of 100 cases are described.

During a period of 2 years, 132 patients with advanced solid cancer were treated with AT-1727 alone in 8 hospitals. The objective drug response was not very marked, only 11.4%(15/132). But if the results are evaluated by the international criteria or by old Chinese criteria of new chemotherapeutic drugs, the response rate is raised to 32.6%(43/132). The therapeutic results of AT-1727 in gastric cancer and external vulva cancer are encouraging. Five of 15 cases of non-Hodgkin's lymphoma had partial remission as did two of 7 cases of Hodgkin's disease. The most important advantage is, AT-1727 has no myelosuppressive toxic effects, occasionally a few patients had very mild leucopenia but never below 3,000/mm3. Mild gastrointestinal tract disorders were noted but in only 1 case did serious vomiting lead to cessation of treatment.

This paper deals with the concepts, significance, methods and important points of epidemiologic study on adverse effects of exposure to environmental pollution, workplace hazards and manufactured products.

In order to clarify the bio-geochemical etiology by examining the relationship between water, soil and diet, effects of preventive measures and results of laboratory experiments, the authors investigated the Keshan disease (KD) epidemic and nonendemic areas in Heilongjiang, Hebei, Shanxi, Shandong, Shaanxi, Sichuan, Yunnari, and Tibet through general clinical examinations and records of diet (1963-1978). The results revealed great differences in water, soil and diet, it is suggested that there is a relationship between natural environment and KD incidence and recognized that environmental chemicals through the water-soil-food chain act upon the human body.

Spasmodic torticollis (ST) is a common neurologic disease. Its main clinical feature is clonic or tonic spasm of cervical muscles, causing much suffering and disability. During the past 6 decades, various surgical procedures have been employed for ST with some success. From Aug 1973 to Dec 1980, we treated 42 ST cases by acupuncture point D'arsonval electrotherapy and faradization satisfactorily obviating surgery and its dangers. 40 of 42 cases were completely cured, 1 markedly improved and 1 improved. The 40 completely cured have resumed work or study without recurrence.