Gout is a common type of arthritis. The elevated blood uric acid level in patients leads to urate deposition in the joint cavity, which can cause acute joint pain and redness. In severe cases, it can lead to joint destruction and deformity, and artificial joint replacement is required in the late stage. Gout patients need long-term uric acid-lowering therapy to maintain normal blood uric acid levels. Gout patients are often complicated with kidney disease. Some studies have pointed out that allopurinol, a commonly used uric acid-lowering drug, may increase the risk of all-cause death in patients with chronic kidney disease. Therefore, clinicians are likely to worry about the safety of allopurinol when facing such patients, thus delaying treatment, which eventually leads to acute gout attacks and even serious consequences such as joint destruction and accelerated progression of deformity.
