1991年 · 第07卷第05期

17 diabetic patients with albuminuria were treated with captopril. The dosage was from 37.5 to 200 mg daily for 4 week period. After treatment with captopril the systolic and diastolic pressure was decreased remarkedly. The urinary albumin was reduced from 249.0 μg/min to 94.8 ug/min. The urinary albumin in 8 patients with microalbuminuria was also reduced. No serious side effects were observed Captopril may delay the progress of diabetic nephropathy.

Seventeen plasma free amino acid contents from 10 diabetic nephropathy patients were assayed by Beckman 121MB amino acid analysor and compared with those from 10 normal subjects. The results showed that in diabetic nephropathy, plasma total amin acid glucogenic amino acid, glucogenic and ketogenic amino acid, aromatic amino acid, thrionine (serine), proline, glycine, alanine, tyrosine, phenylalanine and tryptophine revered high significant decrease (P<0.01), non-essential amino acid and methionine were significant decrease (P<0.05), while the branched-chain amino acid, ketogenic amino acid, glutamic and cystine showed nonsignificant elevated serum levels (P>0.05). As a consequence of the observed alterations, there is a striking unbalance of amino acid metabolism in the diabetic nephropathy patients. Elevated serum level of branched-chain amino acid indicated an accelerated protein catabolism. Correction of amino acid metabolic disturbance may improve the clinical manifestations.

Plasma cardionatrion (or atrial natriuretic factor, ANF) level was determined with radio-immunoassay (RIA) method in 27 patients with epidemic hemorrhagic fever (EHF) and 50 healthy subjects. The results showed that: 1. the average ANF level in EHF patients was much higher than that of the healthy subjects (1441.85+898.3pg/ml and 268.4+86.9pg/ml respectively, P<0.01); 2. elevation range of ANF level was found correlated with severity and stage of the disease. The mechanism of elevation of ANF in EHF patiente and its clinical significanee are briefly discussed.

The therapeutic effect of hemodilution on renal failure were evaluated in raobits with acute renal failure induced by glycetbl injection. The control group had no therapy. In the experimental group 1 (706 group), isovolemic hemodilution was carried out using 6% hydroxy ethyl starch as diluent, and in the experimental group 2 (Fluosel-DA group), Fluosel-DA as diluent was injected to isovolemic hemodilution. The amount of urine output, blood urea nitrogen (BUN), filtrated exeretion fraction of sodium (FENa), and hemocrit were determined before and 24, 48, 72 hours after glycerol injection, the renal morphologic analysis by light microscopy and electron microscopy were performed 72 hours after glycerol injection in control and 706 groups.

The results showed that hemodilution, induecd by 6% hydroxy ethyl starch, could protect renal function, but perfluochemical whole blood substitute as dhuent had no the role. The mechanisms of hemodilution by 6% hydroxy ethyl starch protecting against acute renal failure in rabbits involved in hemodilution decreasing blood viscosity and increasing cardiac output.

The effect of serum from 48 patients with CRF on lymphocyte transformation and IL-2 production of normal subjects were investigated. The result showed that the serum from such patient had an inhibitory effect on lymphocyte transformation and IL-2 production. However, this effect did not correlated with patients Serum creatinine concentration and BUN. This inhibitory effect decreased markedly or disappeared in hemodialysis patients