Acellular glomeruli of 20 renal biopsied specimens in various glomerular diseases were observed with scanning electron microscope (SEM). In 2 cases of MCD, 5 FSGS and 2 MsPGN, the glomerular basement membranes (GBM) reveal smooth and fine granular surface. In 2 cases of hypertensive renal disease and the sclerosis segments of FSGS and IgA nephropathy, wrinkling GBM appear as accordionlike appearance. In 1 case of MN and 4 membranous LN, GBM reveal diffuse projections peerpndicular to the native GBM. In 1 case of MPGN (typeⅢ), focal projections are seen in some segments of GBM.
The results of observing with SEM may be comrarcd with light and transmission electron microscopic findings and also supplement data of three-dimensional structure alterations in human glomerular diseases.
