Emodin is a natural anthraquinone derivative extracted from rhubarb. It is an effective active ingredient of rhubarb, Polygonum cuspidatum, Polygonum multiflorum and other traditional Chinese medicines, and has wide pharmacological effects[1]。 Kawai et al.[2]Firstly, it was found that emodin could inhibit the growth of mouse leukemia L1210 cells, and then it was found that emodin could inhibit the proliferation of various tumor cells. Emodin has received widespread attention because of its multiple biological activities (such as vasodilator, immunosuppression, liver protection, and anti-tumor effects[3]。 It was found that emodin can significantly inhibit the proliferation of various tumor cells in human liver cancer, lung cancer, ovarian cancer and bladder cancer, and is a potential antitumor drug[4,5,6]。 In this study, the mouse breast cancer 4T was established1The effect of emodin on the radiosensitivity of breast cancer transplanted tumor and its molecular mechanism were discussed in nude mice cell transplanted tumor model, which provided a theoretical basis for studying the radiotherapy mechanism of pancreatic cancer.
