2017年 · 第26卷第05期

Studies have shown that different miRNAs are involved in the development of different tumors, and their expression patterns are specific^[1]。 As a tumor-related gene, miR-15a plays a key role in the regulation of cancer cell apoptosis. Bmi-1, as a transcription factor in PcG family, plays an important role in the development of tumors^[2,3]。 The involvement of Bmi-1 in the regulation of pancreatic cancer cells is very complicated and can be regulated by various miRNAs^[4]While miRNA, as a class of molecular markers closely related to tumors, is closely related to the occurrence and development of tumors, mainly by binding to the 3, UTR region of its target gene, and playing related functions^[5]。 This suggests that the increase of Bmi-1 expression mediated by epigenetic changes can accelerate the development of pancreatic cancer, but specific studies are few. Based on previous work, this study studied the regulation of miR-15a on the expression of Bmi-1 using pancreatic cancer cell line PANC-1 as matrix, and then explored its role in the radiosensitivity of pancreatic cancer cell line PANC-1, so as to reveal its mechanism of action in the treatment of pancreatic cancer.

Radical radiotherapy is the first choice for intermediate and advanced patients, and some patients also need preoperative or postoperative radiotherapy. Then the main cause of postoperative recurrence is radiation resistance^[1]Therefore, improving radiosensitivity is the focus of radiotherapy research for cervical cancer at present. MiRNAs are small non-coding single-stranded RNAs with a length of about 20-22 nucleotides, which play an important role in biotransformation^[2]。 miRNA has a wide range of functions, not only participates in cell differentiation, proliferation and apoptosis, but also has the function of defending against viruses, and may also affect the occurrence and development of tumors^[3]。 miR-124 was found in glioma multiforme^[4]oral squamous cell carcinoma,^[5]Breast cancer, cervical cancer^[6]Isometric expression decreases and plays the role of oncogene. Current studies have shown that miR-124 overexpression can inhibit the proliferation, invasion and metastasis of cervical cancer cells^[7,8]However, the effect of miR-124 overexpression on the radiosensitivity of cervical cancer cells is rarely reported in the literature. In this study, we studied whether miR-124 overexpression can enhance the radiosensitivity of cervical cancer cells and its mechanism of action in HeLa cells of cervical cancer, and provided a scientific basis for the treatment of cervical cancer with miR-124 as the target combined with radiotherapy.

The Varian Medical Linear Accelerator is fully equipped with accessories for multi-gear energy, including wedge plates, electronic wire limiters, and more. The accessory identification method is to set different opening and closing circular holes at the insertion end of the accessory to form a unique code, identify it with an ENCODER on the accelerator nose, and set an accessory interlock to check whether the accessory is installed correctly.

Sponsored by Nasopharyngeal Cancer Professional Committee of China Anti-Cancer Association, Shanghai Anti-Cancer Association and Nasopharyngeal Cancer Professional Committee of Shanghai Anti-Cancer Association, and co-organized by Nasopharyngeal Cancer Diagnosis and Treatment Center of Fudan University, Affiliated Cancer Hospital of Fudan University and Chinese Cancer Journal magazine, the 8th National Nasopharyngeal Cancer Academic Conference and Nasopharyngeal Cancer Standardized Diagnosis and Treatment Training Course successfully concluded in Shanghai from March 17 to 19, 2017. More than 600 people attended the conference, and the participants unanimously praised the wonderful and practical teaching arrangement of this conference.

Spring spits new shoots, and everything grows together. The inaugural meeting of the Radiation Oncology Professional Committee of Bethune Medical Expert Committee, sponsored by Bethune Medical Expert Committee and co-organized by the Radiotherapy Department of Chinese People's Liberation Army General Hospital, was held grandly at 2: 30 pm on March 24th, 2017 in Beijing Ya'ao International Hotel. Qu Baolin, director of the Radiotherapy Department of Chinese People's Liberation Army General Hospital, and Zhang Zehua, secretary-general of Bethune Medical Expert Committee, presided over the meeting. Yu Zonghe, President of Bethune Medical Expert Committee, Jin Yongcheng, President of Beijing Alumni Association of Bethune Medical University, Gao Yumin, President and Vice President of Beijing Alumni Association of Bethune Medical University, Ma Guoqing, Vice President of Bethune Spiritual Research Association, Zhang Zehua, Secretary General of Bethune Medical Expert Committee, Liu Xiaodong, Dean of School of Public Health of Jilin University, Qu Yaqin, Professor of Cancer Center of First Hospital of Jilin University, Qu Baolin, Director of Radiotherapy Center of Chinese People's Liberation Army General Hospital, Li Gaofeng, Director of Radiotherapy Department of Beijing Hospital, Wang Junjie, Director of Cancer Treatment Center and Radiotherapy Department of Peking University Third Hospital, Kang Jingbo, Director of Cancer Diagnosis and Treatment Center of Naval General Hospital, Dong Xiuyue, Director of Editorial Department of Chinese Journal of Radiation Oncology and other more than 100 white medical students in the field of radiotherapy in China gathered in Beijing to witness this great moment. The committee consists of 7 advisory committee members, 10 steering committee members, 52 standing committee members and over 200 members.