Volume 51 ·  Issue 09 ·  2015

Eye drops are the most commonly used preparations in ophthalmology. Preservatives are usually added in order to protect eye drops against pathogenic organisms and increase the solubility of the drugs in multi-dose containers. Ophthalmologists have paid a lot of attention to the preservatives in eye drops because they remain one of the main reasons for ocular surface damage, and even may lead to serious visual impairment in patients with inappropriate use of eye drops. However, it should be noted that the dangers of preservatives become overstated nowadays. It is necessary to completely evaluate the effects of preservatives in ophthalmic preparations, so that ophthalmologists can guide patients to correctly select eye drops containing preservatives and avoid dangerous side effects, according to their eye disease situation, state of tear function and ocular surface changes, cultural background and financial income, cost and benefit and convenience of the use of drugs, and other factors. The direction of the future development in this field is to establish the clinical guideline for use of eye drops containing preservatives, carry out continuing education courses on preservatives and develop ideal preservatives. (Chin J Ophthalmol, 2015, 51: 641-644)

In the field of ophthalmology, the importance of vision is unknown, but some basic problems related to vision are rarely studied. "Exploring the Method of Correct Statistics of Eye Disease Vision Data and True and False Paracentric Dark Spots" in the Academic Debate Column of Chinese Journal of Ophthalmology, Issue 5, 2015^[1](hereinafter referred to as "Exploration") and "Discussion with the author of the article" Exploring the Method of Correct Statistics of Eye Disease Vision Data and True and False Paracentric Dark Spots ""^[2](hereinafter referred to as "Discussion") two articles, on "the nature of vision" carry on the thought-provoking discussion and discussion. The author thinks that the key of the problem lies in the understanding and understanding of "peripheral vision". In order to avoid "each speaks his own words", the main concepts involved and their interrelationships should be sorted out and clarified from the perspective of visual physiology, hoping to lead the discussion in depth and reach a consensus.

Infectious keratitis is a serious eye disease that may cause blindness. Currently, microbial culture remains the gold standard for diagnosis of many ocular infections, but the technique is limited by low sensitivity and time consuming. Developing rapid and sensitive early diagnostic methods for infectious keratitis is important for guiding timely and effective treatment in clinical practice. Molecular diagnostic techniques use detection of specific nucleic acid sequences as evidence for presence of suspected pathogens. This kind of techniques develops very fast because of its sensitive, specific, rapid and highthroughput advantages. In this review, we highlight recent advances in the application of molecular diagnostic techniques in the diagnosis of infectious keratitis, and discuss the problems and prospects of molecular diagnosis for detecting pathogens in keratitis. (Chin J Ophthalmol, 2015, 51: 709-714)

UVA-riboflavin collagen crosslinking was introduced as a clinical application to stabilize the cornea by inducing crosslinks within and between collagen fibers. It has been shown clinically to arrest the progression of keratoconic ectasia. With further researches, the technical methods of collagen crosslinking have been improved, and the treatment range has been increased. This paper covers the researches on the innovative techniques and applications of collagen crosslinking. (Chin J Ophthalmol, 2015, 51: 715-720)