Volume N4  ·   Issue 04  ·  1978

This paper reports the effect of tetramethyl pyrazine on the cardiovascular system and the results of toxicity experiments on it. At the concentration of 0.17 mg/ml, tetramethyl pyrazine can inhibit contraction of the aortic strip induced by adrenal, chloride or potassium chloride, and can raise the hypoxia tolerance of mice. The coronary blood flow of anesthetized dogs is definitely increased, but vessel, resistance is decreased following intravenous injection of tetramethyl pyrazine at doses of 7.5-30 mg/kg. The intravenous injection of tetramethyl pyrazine at a dose of 100 mg/kg can reduce the myocardial, hypoxemia in rabbits caused, by pitressin, though the myocardial, oxygen, consumption tends to increase 5 minutes after injection. Tetramethyl pyrazine injection at a dose of 40 mg/kg improves microcirculation in the mesenteries of rabbits. In vitro, tetramethyl, pyrazine not only inhibits platelet aggregation caused by ADP, but also disaggregates the aggregated, platelets. The intravenous LD50 in mice is 239 mg/kg, but no toxic reaction has been, found in subacute toxicity experiments on dogs.

The authors have analysed the right hand metacarpo-interphalangeal joints in 2 cases of Kaschin-Beck disease. A detailed description of the morphology, pathogenic mechanism and pathomorphological basis of X-ray changes in the articular cartilage and epiphyseal cartilage of the specimens is given, with emphasis on the pathologic changes involved.

Sixteen cases of inflammatory pseudotumor of the lung are reported. The patients' average age was 41 years (12-65 years). The male to female ratio was 6:10. Clinical symptoms were mild in most cases upper respiratory tract or pulmonary injection was found in some. The roentgenographic appearance was that of round, oval, or dumb-bell shaped mass with even density in the lower lung fields. The diameter was 4-5 cm, growth was slow. Pathologically, the pseudotumors were granulomas with multiple cells. The lesion may be categorized into four types according to its dominant cell component, namely, histiocyte hyperplastic type, alveolo-epithetial and vasculo-hyperplastic type, plasma cell granuloma type and pseudolymphoma type. The etiology may be related to some non-specific inflammation or virus infection. Pulmonary inflammatory pseudotumor is a benign lesion in which operation gives good therapeutic results, only a few cases turn malignant.

In 1975, the author and his colleagues reported 60 cases of "adenoma of the lung". The lesion is reported under many names in the literature. In this paper the author reviewed and discussed the related literature and suggested that the term "inflammatory pseudotumor of the lung", embracing lesions pathologically and clinically varying in nature, should be abandoned, and that the term "sclerosing hemagioma of the lung" be replaced by the term "lung adenoma".

The external stabilizing tractor is a newly developed apparatus for correcting chest deformity and especially paradoxical respiration in flail chest. It is simple and easy to handle. The wounded may be safely transported with it in position, making continuity of treatment possible while travelling. This makes the apparatus particularly valuable in treating casualties at the front. The structure and method of application are described in detail.

Clinical studies of 187 and 144 cases of hydrofluoric acid, burns are reported. These burns must be thoroughly flushed with clean water immediately, then sodium bicarbonate and boric acid solution wet dressings are used. Afterwards oleum Lithospermi compositum and fludrocortisone ointment are applied. Calcium iontophoresis can relieve pain immediately. In cases with blisters and tissue necrosis, debridement is necessary. For severe burns, calcium agents and steroids should also be given. The paper summarizes the causes of such burns and suggests some protective measures.

This paper presents the results of 125I-T3 plasma binding ratio test for assessment of thyroid function, the test was done in 160 cases of whom 44 were normal subjects, 38 hyperthyroid (including 29 before therapy and 9 euthyroids after antithyroid drug treatment, 131I or thyroidectomy), 9 hypothyroid, 20 pregnant women and 49 women on oral contraceptive. The data of this series indicated that taking the mean value of the normal group ±1.6 S.D. (i.e., 0.83-1.15) as its upper and lower limits, the percentage of agreement of the normal, hyper and hypothyroid groups, are 88.6%, 90.0%, and 77.8% with certain over-lappings. The percentage of diagnostic agreement of the 131I uptake rate is compared with that of the 125I-T3 plasma binding ratio both for the normal and hyper-thyroid groups. The diagnostic value and limits of the test in assessment of thyroid function were discussed.