2018年 · 第52卷第04期

Microwave ablation (MWA) is now widely used to treat hepatocellular carcinoma (HCC) or metastatic liver tumors. However, similar to radiofrequency ablation (RFA), when the tumor lesion diameter is>3 cm, MWA is prone to residual tumor cells, which leads to local tumor recurrence, and it is difficult to achieve complete and complete ablation^[1]。 Quercetin encapsulated by liposome can enhance its fat solubility, and the neovascular permeability of tumor tissue is greater, which can make quercetin stay concentrated in tumor tissue at higher concentration and for a longer time^[2]。 Studies have shown that intravenous liposomal quercetin (LQ) can induce apoptosis by inhibiting the expression of heat shock protein 70 (HSP70) and altering its distribution in hepatocytes, thereby enhancing the coagulative necrosis of tumor tissue caused by RFA. Wan et al.^[3]It was found that residual tumor cells could survive in the peripheral transition zone after RFA ablation, and the surviving tumor cells promoted the overexpression of HSP70, which in turn accelerated the proliferation of residual tumor cells and the formation of new blood vessels. This study was to investigate the underlying mechanism of the effect of intravenous LQ on MWA by examining the changes in HSP70 expression levels in normal liver tissues in the peripheral region of MWA to determine whether intravenous LQ increases the effect of MWA-induced hepatic parenchyma ablation.

Hepatic lymphangioma is an extremely rare benign tumor. The author analyzed the clinical, imaging and pathological data of 3 patients with hepatic lymphangioma confirmed by pathology, and reviewed the relevant literature. The report is as follows, aiming at improving the understanding of the imaging manifestations of this disease.

Central scar is a relatively rare imaging sign in liver mass lesions, but it has important differential diagnostic value for benign tumor focal nodular hyperplasia (FNH)^[1]。 Central scars can also be seen in other neoplastic lesions, such as larger hemangiomas, fibrolamellar hepatocarcinoma, and intrahepatic cholangiocarcinoma^[2]However, scar signs occurring in hepatocellular carcinoma (HCC) have only been reported in individual cases^[3]。 The purpose of the author was to explore the MRI manifestations and pathological basis of central scar.

The child was a 3-month-old male who had a full-term cesarean section. On June 10, 2016, he was admitted to our hospital with cough, phlegm in the throat and feeding difficulty for 1 week. hypophosphatasia (HPP) was diagnosed by genetic testing in other hospitals. After admission, pulmonary CT was performed with plain radiographs of limbs and brain CT to evaluate the disease.

Congenital chondrodystrophy, also known as chondrodysplasia punctata (CDP) or spotted cartilage dysplasia, is clinically rare, with a prevalence of about 1:10 000 live infants^[1]One case of CDP diagnosed and treated in our hospital is now reported.

Vascular abnormalities are accompanied by the occurrence and development of many diseases, and are likely to cause a series of more dangerous pathophysiological changes. With the increasing improvement of imaging equipment and image processing technology, 3D angiography can observe the morphological changes of blood vessels without destruction in vivo, and perform qualitative and quantitative analysis. In the late 1990s, it was reported that micro-CT (micro-CT) was used for 3D imaging of small animal blood vessels^[1]Based on its ultra-high spatial resolution and the gradual development of contrast agents, micro-CT has become an important tool for vascular imaging in animal experiments. The vascular reconstruction images obtained by micro-CT can even strictly match the tissue section images^[2]。 The author reviews the characteristics of micro-CT technology and its application in animal experiments.