Case 1: A 50-year-old female was admitted to the hospital due to "middle and upper abdominal discomfort for more than 1 year". The patient had a history of breast cancer surgery for 10 years, and was pathologically diagnosed as invasive lobular carcinoma of the breast, stage III. Chemotherapy, radiotherapy and endocrine therapy were given after operation. Gastroscopy: 3~4 mucosal fading changes were observed in each wall of the stomach body, and 1 mucosal fading change was observed near the gastric angle of the stomach body, all of which were Ⅱb lesions, atypical metastatic crater-like bulging lesions + central depression; Narrow-band light imaging + magnified endoscopic observation: Part of the glandular duct of the lesion was missing, the peripheral glandular duct was slightly thicker, the internal microvessels were obviously thickened and uneven in size, and there were multiple mucosal fading lesions in the gastric body (Figure 1). Pathology: Atypical cells arranged in a cord-like manner were seen in the stomach (Figure 2A). Immunohistochemistry: Ki-67 (+) 5%, GATA-binding protein 3 (GATA-3) (+), E-Cadherin (+), P120 (membrane +), estrogen receptor (ER) (+) 50%, progesterone receptor (PR) (+) 5%, human epidermal growth factor receptor-2 (HER2) (+), and vesicular disease fluid protein-15 (GCDFP-15) (+) (Figures 2B ~2F). Combined with the patient's previous medical history and immunohistochemical results, it was consistent with breast cancer metastasis. The chemotherapy regimen was adjusted to docetaxel + capecitabine. Currently surviving with tumor.
