2020年 · 第40卷第12期

Radiotherapy is a local treatment method that uses radiation to treat tumors. It is based on various radiation devices and radioactive source applications, and is an important application of ionizing radiation technology in modern medicine. Like other applications of ionizing radiation technology, radiotherapy, while using ionizing radiation technology to treat tumors, may also pose potential health hazards to relevant professionals and the public. Therefore, it is necessary to continuously improve the radiation protection standards to meet the radiotherapy needs of cancer patients on the premise of effectively protecting the health and safety of relevant professionals and the public.

On September 18, 2020, the team of Liu Qiang, a researcher at the Institute of Radiation Medicine, Chinese Academy of Medical Sciences, published a presentation on Nucleic Acids Research entitled "NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest" The latest research results of. This study found for the first time that after ionizing radiation induced DNA damage, NRF2 protein was recruited to the DNA damage site and interacted with ATR, thereby activating the ATR-CHK1-CDC2 signaling pathway, promoting G2 phase cell cycle arrest and DNA damage through homologous recombination Repair to maintain the stability of the genome. The results of this study reveal for the first time the novel function of NRF2 as an ATR activator to promote DNA damage repair.