2017年 · 第37卷第06期

Cancer patients after receiving radiotherapy cause a series of radiation damage, such as radiation oral mucositis, radiation enteritis, etc., which seriously affects the recovery. Radiation damage to gastrointestinal tract can lead to diarrhea, leading to electrolyte imbalance and dehydration, inability to absorb water, protein and other nutrients in food, which is the most common and important adverse reaction in radiotherapy^[1]。 Sodium butyrate is a functional substance produced by intestinal flora fermentation, which plays an important role in cell proliferation and integrity^[2]。 At the same time, butyrate is well tolerated in patients with enteritis^[3]Sodium butyrate has a certain protective effect on experimental colitis induced by trinitrobenzenesulfonic acid^[4]。 However, there are no reports on whether local radiation-induced intestinal injury has an effect. The purpose of this study is to investigate whether sodium butyrate has the effect of protecting radiation-induced intestinal injury through the rat model of intestinal injury induced by irradiation, and to study its possible mechanism of action.

Personal dose monitoring of radiation workers plays a pivotal role in the field of occupational radiation protection. Personal dose monitoring data is not only the main basis for occupational health monitoring, radiation disease diagnosis and evaluation of radiation hazards of radiation workers, but also the main means for evaluating radiation protection efficiency, management level and physical dose estimation of sudden radiation accidents. The results of personal dose monitoring of external exposure of some radiation workers in Shaanxi Province from 2008 to 2015 are analyzed and reported as follows.