2016年 · 第36卷第01期

The research and development of nuclear weapons includes "spear" (nuclear weapons) and "shield" (nuclear protection), which are two aspects of great national strategic significance. Nuclear tests not only verify the explosive power of nuclear weapons, which provides a basis for improving research and development, but also conduct multiple effect tests to study the killing and destructive effects of nuclear weapons, which provides a basis for defense and protection. The animal effect of nuclear test is an important part of nuclear protection research. Through the animal effect (laboratory animals make sacrifices for human beings), the study of various injuries caused by nuclear weapon explosions to personnel and medical protection lays the foundation for casting "medical nuclear shield".

Radiation brain injury (RBI) is a common complication after radiotherapy in patients with craniocerebral tumors, which seriously affects the therapeutic effect and quality of life of patients. It was found that inflammatory response plays an important role in the occurrence and development of RBI, and is the main factor in the acute and late secondary damage of brain tissue after being exposed to ionizing radiation^[1]。 Cyclooxygenase-2 (Cox-2) is an inducible enzyme, which is not only regulated by various growth factors and inflammatory mediators, but also mediates the synthesis of various prostaglandin substances, and then generates various inflammatory factors, which participate in various physiological and pathological processes in the body by waterfall cascade reaction. There are many mature anti-inflammatory drugs for this target in clinic^[2]。 This study aims to explore the dynamic changes of Cox-2 in RBI through gene, protein and functional localization, and hopes to provide some ideas and basis for the clinical use of selective Cox-2 inhibitors in the treatment of RBI.

The main reasons for the failure of esophageal cancer after radiotherapy are local uncontrolled and recurrence. At the same time, inaccurate target localization (off-target) is also a factor that cannot be ignored in treatment failure. In recent years, precise radiotherapy (three-dimensional conformal radiotherapy or intensity modulated radiotherapy) has been used in esophageal cancer, and the determination of therapeutic target area is the fundamental of precise radiotherapy. Simulated CT is a direct source of information to delineate the tumor target volume (GTV), but it is not accurate enough to locate the tumor head-tail direction (longitudinal GTV). At present, in order to improve the accuracy of esophageal target delineation, sclerosing agent is generally injected at the tumor boundary^[1]Ultrasound-guided metal marker implantation^[2]Metal titanium clip mucosal and submucosal fixation and other marking methods^[3]。 However, injection of sclerosing agent at the border of tumor is easy to spread. Although ultrasound-guided metal markers are more stable, they have more complications. This study investigated the application of endoscopic titanium clip labeling in three-dimensional conformal radiotherapy target delineation of esophageal cancer.

Medical radiation safety is related to the health and life safety of radiation workers, patients and the public in medical and health institutions. In order to comprehensively understand the current situation of medical radiation protection in Ningxia, strengthen the supervision and management of radiation work, and protect the health rights and interests of radiation workers, patients and the public in medical and health institutions. According to the Work Plan of Medical Radiation Protection Monitoring Project of Medical and Health Institutions in 2014 (hereinafter referred to as the Work Plan) of the National Health and Family Planning Commission, Ningxia Center for Disease Control and Prevention has carried out radiation protection monitoring of radiation diagnosis and treatment institutions. The monitoring results are reported as follows.